WebbThe inherent flexibility of intrinsically disordered proteins (IDPs) makes it difficult to interpret experimental data using structural models. On the other hand, molecular dynamics simulations... WebbSteiner et al. demonstrate that PTEN deletion in luminal prostate cell causes an expansion of transformed LY6D+ progenitor cells with intrinsic castration-resistant properties through autocrine AREG-mediated MAPK activation. Pharmacological interference of MAPK pathway overcomes the castration-resistance properties of LY6D+ cells, providing a …
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Webb10 apr. 2024 · Background Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of cancer-related death across the world with the limited efficiency and response rate of immunotherapy. Protein S-palmitoylation, a powerful post-translational lipid modification, is well-known to regulate the stability and cellular distribution of cancer … Webb16 aug. 2004 · There exists a second subclass of enzyme-associated receptors that do not possess intrinsic tyrosine kinase activity but rather have an associated partner protein … paint informacje
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WebbNO-self enzymatic activity-also called receptor tyrosine kinases OR ligand-triggered protein kinases-similar to tyrosine-linked receptors - ligand binding results in formation of a … WebbWhen the nuclear estrogen receptors bind (ligand) compounds such as the natural estrogens, the receptors are stereo-chemically rearranged, which allows them to pair as receptor dimers. 53 As the dimers enter the nucleus they are further regulated by tissue-specific co-trans-activation factors, and then, next to estrogen response elements (ERE) … WebbTyrosine-Kinase Associated Receptors • associate with intracellular proteins that have tyrosine kinase activity. These receptors lack the tyrosine kinase domain that was discussed earlier and, therefore, … subway racers game