Cryptophycine
WebJul 15, 2016 · Abstract. Cryptophycins are a class of macrocyclic depsipeptides produced as secondary metabolites by cyanobacteria of the genus Nostoc and were found to bind to microtubules at the vinca site. The natural product C-1 isolated in 1990 and the synthetic derivative C-52 displayed potent in vitro and in vivo antitumor activity in preclinical …
Cryptophycine
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WebCryptophycin 1, produced by Nostoc sp. GSV 224, is a potent cytotoxic anti-microtubule agent. Cryptophycin 1 can induce cell apoptosis, and has anti-tumor activity and excellent anti-proliferation ability. Category ADCs Cytotoxin Product Name Cryptophycin 1 CAS 124689-65-2 Catalog Number BADC-00569 Molecular Formula C35H43ClN2O8 Molecular … WebThe TE domain on the enzymatic assembly line converts the intermediate shown below to Cryptophycin 24. In 1-2 sentences, specify whether the TE domain catalyzes the hydrolysis or the cyclization (macrolactonization) to generate Cryptophycin 24 and explain one feature of the TE domain that will enable the desired reaction outcome.
WebSep 27, 2010 · File:Cryptophycine (color).svg From Wikimedia Commons, the free media repository File File history File usage on Commons File usage on other wikis Size of this PNG preview of this SVG file: 800 × 519 pixels. Other resolutions: 320 × 208 pixels 640 × 415 pixels 1,024 × 664 pixels 1,280 × 830 pixels 2,560 × 1,661 pixels 803 × 521 pixels. WebCryptophycin-52 (Cp-52) is potentially the most potent anticancer drug known, with IC50 values in the low picomolar range, but its binding site on tubulin and mechanism of action are unknown. Here, we have determined the binding site of Cp-52, and its parent compound, cryptophycin-1, on HeLa tubulin, to a resolution of 3.3 Å and 3.4 Å, respectively, by cryo …
WebJun 29, 2024 · Cryptophycin-8, the chlorohydrin of cryptophycin-1, showed high antitumor activity in vivo against a number of MDR tumors, and moreover, it was found to be less … WebCryptophycin 52 has demonstrated a broad range of antitumor activity against both murine and human tumors. In the human MX-1 breast carcinoma xenograft cryptophycin 55 produced greater-than- additive tumor response in combination with 5-fluorouracil. In human non-small cell lung carcinoma and human small cell carcinoma xenografts ...
WebCryptophycin is a class of cyclic depsipeptides that was originally isolated from the cyanobacteria Nostoc sp. (Figure 1, right) in 1990 by researchers at Merck as a potent fungicide, however, the compound was found to be highly toxic to be developed as antifungal. Some years later, crypthophycins were discovered to be potent cytotoxins.
WebCryptophycin 4 C35H44N2O7 CID 101025283 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... hvl radiationWebThis invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic. hvl-rs4 recboxWebThe cryptophycin will be eluded in 65% aqueous acetonitrile fraction. The medium will be passed through an extraction column (see objective 2 for detail) and then eluded with 65% … mas 36 rifle ww2