WebIn addition, CLDN proteins may act through highly specific intracellular signaling pathways, but the mechanism of most CLDN proteins in tumors is currently unknown. Numerous …
Overexpressed claudins in AGS cells are localized in the cytosol. (a ...
WebDec 10, 2024 · Citation 77 TNF-α/NF-ƙB and TGF-β-Smad/Snail pathways are the major regulators of CLDN expression. Other pathways reported to be involved in the … WebFeb 20, 2024 · Due to the lack of timely and accurate screening modalities and treatments, most pancreatic cancer (PCa) patients undergo fatal PCa progression within a short period since diagnosis. The claudin (CLDN) family is expressed specifically as tight junction structure in a variety of tumors, including PCa, and affects tumor progression by … mogseat ffxiv
Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway …
WebApr 6, 2024 · In conclusion, SCF/c-kit-JNK/AP-1 signaling pathway significantly promoted claudin-3 expression in colonic epithelium and CRC, which could contribute to epithelial barrier function maintenance and to CRC development. ... We found that CLDN-3 promoter region harbored the binding sites of AP-1/c-Jun, which was an important downstream ... WebJan 15, 2024 · Claudin (CLDN)-1 is the most-studied claudin in cancers and to date, its role as either a tumor promoter or suppressor (or both) is not established. In some cancers, … WebMicroRNAs (miRNAs) involved in the SOX9-CLDN pathway were predicted with bioinformatics analysis, and the upstream molecular mechanism was interpreted using MassARRAY methylation detection.... mogsc membership